AncestryDNA® Traits Learning Hub

If you can comfortably jog, walk, or bike a few miles, you likely have good endurance fitness. Some elite athletes, like marathoners, have very high levels. Exercising regularly is the best way to build endurance fitness and to support your overall fitness level.
But genetics matters, too. AncestryDNA® + Traits looks at over 15,000 DNA markers associated with endurance fitness, ones that align with activities like endurance running, for example.
Aerobic activity builds endurance fitness by increasing your heart rate and making you breathe more (aerobic means "with oxygen"). The more aerobically fit you are, the more efficiently your heart pumps and the oxygen can get to your muscles. Cardiovascular workouts like brisk walking, jogging, long-distance running, swimming, cycling, cross-country skiing, jumping rope, and dancing are examples of endurance exercise.
Also, different types of muscle fibers support different types of exercise. For endurance activities, your body relies on slow-twitch muscle fibers, which resist fatigue and have more blood supply. By contrast, power sports like weightlifting or sprinting rely on fast-twitch muscles.
Building endurance fitness has many health benefits, including reducing your risk for heart disease. It may also help you better control your blood sugar, which reduces your risk for type 2 diabetes. Aerobic exercise (aka "cardio") also helps prevent many types of cancer, improves people's quality of life, and helps people of all ages manage depression and anxiety.
This is why the U.S. Department of Health and Human Services recommends that adults get at least 150 minutes—or 2.5 hours—of moderate intensity aerobic exercise each week. Brisk walking is considered "moderate intensity," whereas long distance running is considered "high intensity." People who want to get the most benefits should aim for 300 minutes—or 5 hours—per week.
Scientific research shows that genetic factors play a part in endurance fitness. In studies comparing athletes and non-athletes, scientists have linked several hundred genetic variants to differences in athletic performance.
When Ancestry scientists looked at the 15,000-plus DNA markers associated with differences in endurance fitness, they included markers found in the genes PPARAGC1β, HIF1A, and ADRB2. Differences at these DNA markers may affect things like muscle performance, body oxygen levels, and heart rate.
Importantly, the scientific consensus is that each genetic difference likely only makes a small contribution to someone's overall endurance fitness. Endurance training, effort, and resources will factor more into athletic success.
How do you explain families of talented runners? It's likely a combination of genetics plus environmental and behavioral factors, i.e., lifestyle. For example, families and communities that live at high elevations tend to have increased lung capacity compared to lower-elevation communities. So can living in a city with a top-notch running program, or parents making a habit of running with their kids.
Another factor is VO2 max, or the maximum amount of oxygen your body can use during exercise. The higher your VO2 max, the better endurance you'll have. A high VO2 max also means a lower risk of heart disease. But you can still increase your VO2 max with regular exercise in just about any location—at the gym, on a trail, or in the pool, for example.
What does your DNA say about endurance fitness? An AncestryDNA® + Traits test can tell whether you’re more or less likely to carry the genes for endurance activities like long-distance running, biking, or swimming.
References (all accessed May 24, 2023)
"Aerobic Exercise." Cleveland Clinic. https://my.clevelandclinic.org/health/articles/7050-aerobic-exercise.
"Endurance Exercise (Aerobic)." American Heart Association. https://www.heart.org/en/healthy-living/fitness/fitness-basics/endurance-exercise-aerobic.
Hutchinson, Alex. "Should Your Doctor Check Your VO2 Max?" Runner's World. https://www.runnersworld.com/health-injuries/a20836245/should-your-doctor-check-your-vo2-max/.
"Is Athletic Performance Determined by Genetics?" MedlinePlus. U.S. National Library of Medicine. https://medlineplus.gov/genetics/understanding/traits/athleticperformance/.
Moir, Hannah J, Rachael Kemp, et al. "Genes and Elite Marathon Running Performance: A Systematic Review." Journal of Sports Science & Medicine, August 1, 2019. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683622/.
Penney, Stacey. "Fast-Twitch vs. Slow-Twitch Muscle Fiber Types + Training Tips." NASM. https://blog.nasm.org/fitness/fast-twitch-vs-slow-twitch.
"Physical Activity Guidelines for Americans 2nd Edition." health.gov. https://health.gov/sites/default/files/2019-10/PAG_ExecutiveSummary.pdf.
Ross, Robert, Steven N. Blair, et al. "Importance of Assessing Cardiorespiratory Fitness in Clinical Practice: A Case for Fitness as a Clinical Vital Sign: A Scientific Statement From the American Heart Association." Circulation. American Heart Association, November 21, 2016. https://www.ahajournals.org/doi/full/10.1161/CIR.0000000000000461.
"Top 10 Things to Know About the Second Edition of the Physical Activity Guidelines for Americans." health.gov https://health.gov/our-work/nutrition-physical-activity/physical-activity-guidelines/current-guidelines/top-10-things-know.